Lacidofil

General characteristics:
Main physical and chemical properties: transparent gelatin capsules of yellowish color which contain fine ivory powder with little beige specks;

Composition: each capsule contains 2 billion of lyophilized bacteria Lactobacillus acidophilus R052, Lactobacillus rhamnosus R011; ingredients: ascorbic acid, magnesium stearate, maltodextrine.
Form of production: capsules.

Immunological and biological properties: Capsule form of living frozen-dried lactic acid bacteria are used to prevent antibiotic associated diarrhea during antibiotic therapy, to restore and normalize intestinal microflora, to treat gastroenteritis and dyspepsia, to improve digestion and increase tolerance to milk lactose, for supporting therapy of necrotic enterocolitis in newly born babies.

Pharmacocinetics: Lactobacteria: Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R052 completely goes out of the intestine in 7-15 days after treatment with Lacidofil. Rapidly growing lactic acid bacteria in intestine contributes to normalization of microflora and provides anti-bacterial effect to pathogenic and opportunistic microorganisms due to strengthening of physical barrier and increase of local immunity. Lactobacillus rhamnosus R0011 is able to decrease allergic reaction of the organism and increase tolerance to milk lactose.

Indications for use:

Prevention and treatment of diarrhea caused by most antibiotics and especially lincomicine, clindamicine, ampicilline, amoxicilline and caphalosporines. The preparation is specific for prevention of Clostridium-difficile infection.
In complex treatment of stomach and duodenum from Helicobacter pylori associated diseases together with antibacterial therapy.
Restoration and normalization of intestinal microflora, improvement of digestion.
Treatment of gastroenteritis, dyspepsia.
As a part of complex therapy of necrotic enterocolitis in newly born babies.
Treatment of transitory functions of the bowel (both diarrhea and constipation) caused by change of diet, traveling and other reasons.
As a part of complex therapy of atopic dermatitis.
Increase of tolerance to milk lactose.
As preventive measure of atopy in children (indication of Lacidofil to pregnant women and then to her newly born baby)
Improvement of the skin microflora.
Improvement of condition in case of chronic fatigue syndrome.

Usage method and dosage. A capsule is taken with a small amount of water during meal. For children below 3 years of age the capsule has to be opened and the content mixed with cold water or cold food.

1. Prophylaxis to maintain normal microflora of the bowel:
Children newly born - 3 years old - 1 capsule every other day.
Children over 3 years and older – 1 capsule one time per day.
Adults – 1 to 2 capsules one time per day.
Duration of treatment – 20 days.

2. Prophylaxis and treatment of diarrhea caused by antibiotic therapy (including diarrhea caused by Clostridium difficile): Lacidofil should be taken separately from antibiotics, two hours before or after antibiotics:
Children newly born -12 months – 1 capsule daily.
Children from 1 year to 3 years – 1 capsule two times per day.
Children from 3 to 12 years – 1 capsules two-three times per day.
Children over 12 years and adults – 1-2 capsules three times per day.
Duration of treatment should be based on duration of antibiotic treatment. In treatment of diarrhea caused by antibiotic therapy – till the symptoms of the disease are gone. Further, the preparation can be used for prophylaxis (see item 1).

3. Treatment of transitory bowel dysfunction (both diarrhea and constipation) caused by change of diet, traveling and other reasons:
Children newly born -12 months – 1 capsule daily.
Children from 1 year to 3 years – 1 capsule two times per day.
Children over 3 years – 1 capsule three times per day till the symptoms disappear. In case of necessity the dosage can be increased up to 1-2 capsules three times per day.
Adults – 1-2 capsules three times per day till the symptoms disappear.
Further, the preparation can be taken for maintaining the intestinal microflora (see item 1).

4. Treatment of atopic dermatitis
Children up to 3 years – 1 capsule two times per day during 1-1,5 months.

Interaction with other medicines: Administration Lacidofil per or simultaneously with antibiotics is less efficient. Lacidofil should be taken within 2 hours after consumption of antibiotics.

Side effect: none

Contra-indications: none

Special notes:
There was not a single case of Lacidofil negative effect. However, there are several patient groups (adults and children), whose condition should be evaluated during treatment by any probiotic. The following groups of patients can be treated by probiotics but under supervision of a physician.

Patients with impaired or depressed immune system, especially patients at late stages of AIDS, or patients with allotransplants, and those being treated by chemotherapy.
Patients who suffer from endo- and myocarditis, and those operated on the colon, mouth and teeth.
Children suffering with the short bowel syndrome.
Patients suffering from bloody diarrhea.

In all cases mentioned above the favorable effect of probiotics overweights possible risks.

Storage conditions: Lacidofil should be kelp in refrigerator at the temperature of + 4о С .

Shelf life: 2 years.

Conditions of sale: Without prescription.

Package: 20 capsules in a cupboard box. The box contains two blisters, 10 capsules in each blister.

Manufacturer: Institute Rosell Inc., Canada